Mouse Monoclonal Antibody to NBN
货号：
30608
别名：
ATV; NBS; P95; NBS1; AT-V1; AT-V2
应用：
WB,IHC,IF,FCM
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
O60934
规格：
目录价
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Description |
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Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. |
References |
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| 1. Fam Cancer. 2012 Dec;11(4):595-600. 2. Mol Carcinog. 2011 Sep;50(9):689-96. |
Specification |
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| Aliases | ATV; NBS; P95; NBS1; AT-V1; AT-V2 |
| Entrez GeneID | 4683 |
| Swissprot | O60934 |
| clone | 7E4C2 |
| WB Predicted band size | 85kDa |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human NBN (AA: 467-615) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500 - 1/2000 |
| IHC | 1/200 - 1/1000 |
| IF | 1/200 - 1/1000 |
| FCM | 1/200 - 1/400 |
| ELISA | 1/10000 |
Product Image
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Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
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Western blot analysis using NBN mouse mAb against Jurkat (1) cell lysate.
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Immunofluorescence analysis of Hela cells using NBN mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)
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Flow cytometric analysis of Hela cells using NBN mouse mAb (green) and negative control (red).
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Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using NBN mouse mAb with DAB staining.
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Immunohistochemical analysis of paraffin-embedded human colon cancer tissues using NBN mouse mAb with DAB staining.
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