Mouse Monoclonal Antibody to TCL1A
货号：
30715
别名：
TCL1
应用：
FCM
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
P56279
规格：
目录价
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Description |
|---|
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]). |
References |
|---|
| 1. Blood. 2012 Aug 23;120(8):1613-23. 2. Histopathology. 2010 Jul;57(1):152-7. |
Specification |
|
|---|---|
| Aliases | TCL1 |
| Entrez GeneID | 8115 |
| Swissprot | P56279 |
| clone | 2E3A5 |
| WB Predicted band size | 13.5kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human TCL1A (AA: 10-104) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| FCM | 1/200 - 1/400 |
| ELISA | 1/10000 |
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