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Mouse Monoclonal Antibody to SLINGSHOT-1L
货号: 30742
别名: SSH1;SSH1L
应用: IHC,FCM
反应种属: Human
抗体类型: Primary antibody
Swissprot: Q8WYL5
规格:
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Description

The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

References

Molecules. 2012 Dec 17;17(12):14975-94.
Nan Fang Yi Ke Da Xue Xue Bao. 2011 Jun;31(6):928-32.

Specification

Aliases SSH1;SSH1L
Entrez GeneID 54434
Swissprot Q8WYL5
clone 6C11G9
WB Predicted band size 115.5kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Synthesized peptide fragment of human SLINGSHOT-1L (AA: 1032-1044 ) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

IHC 1/200 - 1/1000
FCM 1/200 - 1/400
ELISA 1/10000
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