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Mouse Monoclonal Antibody to MAP3K7
货号: 30765
别名: TAK1; MEKK7; TGF1a
应用:
反应种属: Human
抗体类型: Primary antibody
Swissprot: O43318
规格:
目录价
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Description

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

References

Asian Pac J Cancer Prev. 2013;14(1):315-20.
Blood. 2012 Jul 12;120(2):347-55.

Specification

Aliases TAK1; MEKK7; TGF1a
Entrez GeneID 6885
Swissprot O43318
clone 3E8H4
WB Predicted band size 67.2kDa
Host/Isotype Mouse IgG2a
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human MAP3K7 (AA: 471-579) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide and 0.5% protein stabilizer.

Application

ELISA 1/10000
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