Rabbit Monoclonal to SESN1
货号：
P18259
别名：
PA26; sesn1; SEST1; sestrin 1;;Sestrin 1
应用：
WB;FCM
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
Q9Y6P5
规格：
目录价
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Description |
|---|
Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway. |
Specification |
|
|---|---|
| Aliases | PA26; sesn1; SEST1; sestrin 1;;Sestrin 1 |
| Swissprot | Q9Y6P5 |
| WB Predicted band size | Calculated MW: 57 kDa ; Observed MW: 70 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Sestrin 1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
Application |
|
|---|---|
| WB | 1/1000-1/2000 |
| FCM | 1/20-1/100 |
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