Rabbit Monoclonal to HIF1AN
货号：
P18317
别名：
FIH 1; FIH1; HIF1AN;;HIF 1 alpha inhibitor
应用：
WB,IHC/IHF,IF,FCM
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
Q9NWT6
规格：
目录价
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Description |
|---|
Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. |
Specification |
|
|---|---|
| Aliases | FIH 1; FIH1; HIF1AN;;HIF 1 alpha inhibitor |
| Swissprot | Q9NWT6 |
| WB Predicted band size | 40 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human HIF 1 alpha inhibitor |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
Application |
|
|---|---|
| WB | 1/1000-1/2000 |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 |
| IF | 1/50-1/200 |
| FCM | 1/20-1/100 |
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