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Mouse Monoclonal Antibody to ERCC1
货号: 30827
别名: UV20; COFS4; RAD10
应用: FCM
反应种属: Human
抗体类型: Primary antibody
Swissprot: P07992
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Description

The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.

References

1.Tumour Biol. 2014 Sep;35(9):8721-31.
2.Anticancer Res. 2014 Jan;34(1):401-6.

Specification

Aliases UV20; COFS4; RAD10
Entrez GeneID 2067
Swissprot P07992
clone 1A5A2
WB Predicted band size 32.6kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human ERCC1 (AA: 151-297) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

FCM 1/200 - 1/400
ELISA 1/10000
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