Rabbit Monoclonal to RGMA
货号：
P18906
别名：
Repulsive guidance molecule A; RGM; RGM domain family member A; RGMA;;Repulsive guidance molecule A
应用：
WB,IF
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
Q96B86
规格：
目录价
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Description |
|---|
Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. |
Specification |
|
|---|---|
| Aliases | Repulsive guidance molecule A; RGM; RGM domain family member A; RGMA;;Repulsive guidance molecule A |
| Swissprot | Q96B86 |
| WB Predicted band size | Calculated MW: 49 kDa ; Observed MW: 37 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Repulsive guidance molecule A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
Application |
|
|---|---|
| WB | 1/1000-1/2000 |
| IF | 1/50-1/200 |
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