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Mouse Monoclonal Antibody to PLCG1
货号: 30861
别名: PLC1; NCKAP3; PLC-II; PLC148; PLCgamma1
应用: WB,IHC,IF,FCM
反应种属: Human,Rat,Monkey
抗体类型: Primary antibody
Swissprot: P19174
规格:
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Description

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.

References

1.Cancer Discov. 2014 Apr;4(4):OF13.
2.Int J Cancer. 2013 Mar 1;132(5):1022-31.

Specification

Aliases PLC1; NCKAP3; PLC-II; PLC148; PLCgamma1
Entrez GeneID 5335
Swissprot P19174
clone 3C2D11
WB Predicted band size 148.5kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human,Rat,Monkey
Immunogen Purified recombinant fragment of human PLCG1 (AA: 1192-1291) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

WB 1/500 - 1/2000
IHC 1/200 - 1/1000
IF 1/200 - 1/1000
FCM 1/200 - 1/400
ELISA 1/10000
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