Rabbit Monoclonal Antibody to DOCK8
货号：
P21328
别名：
MRD2; ZIR8; HEL-205
应用：
WB,IF
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
Q8NF50
规格：
目录价
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Description |
|---|
Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP (PubMed:28028151, PubMed:22461490). During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC . Required for CD4+ T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane (PubMed:28028151). Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (PubMed:25762780). |
Specification |
|
|---|---|
| Aliases | MRD2; ZIR8; HEL-205 |
| Entrez GeneID | 81704 |
| Swissprot | Q8NF50 |
| WB Predicted band size | Calculated MW: 239 kDa; Observed MW: 239 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Recombinant protein of human DOCK8 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
Application |
|
|---|---|
| WB | 1/500-1/1000 |
| IF | 1/50-1/200 |
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