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Rabbit Monoclonal Antibody to HP1 gamma
货号: P21522
别名: HECH; HP1-GAMMA; HP1Hs-gamma; CBX3
应用: WB,IP,IHC
反应种属: Human,Mouse,Rat
抗体类型: Primary antibody
Swissprot: P23198
规格:
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Description

Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Probably involved in the repression of many genes located in euchromatin, such as E2F1, MYC and CDC25A. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1.

Specification

Aliases HECH; HP1-GAMMA; HP1Hs-gamma; CBX3
Entrez GeneID 12417
Swissprot P23198
WB Predicted band size Calculated MW: 21 kDa; Observed MW: 21 kDa
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human,Mouse,Rat
Immunogen A synthetic peptide of mouse HP1 gamma
Formulation Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

Application

WB 1/500-1/1000
IP 1/10-1/20
IHC 1/50-1/100
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