产品中心
PRODUCT CENTER
首页 »产品中心 »抗体 »科研抗体 »
Mouse Monoclonal Antibody to AKT1
货号: 30996
别名: AKT; PKB; RAC; CWS6; PRKBA; PKB-ALPHA; RAC-ALPHA
应用: WB,IF,FCM
反应种属: Human,Mouse,Monkey,Rat
抗体类型: Primary antibody
Swissprot: P31749
规格:
目录价
在线咨询

Description

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.

References

1.Sci Rep. 2015 Jan 13;5:7758.
2.J Cancer Res Clin Oncol. 2015 Apr;141(4):615-26.

Specification

Aliases AKT; PKB; RAC; CWS6; PRKBA; PKB-ALPHA; RAC-ALPHA
Entrez GeneID 207
Swissprot P31749
clone 1F7E10
WB Predicted band size 55.7kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human,Mouse,Monkey,Rat
Immunogen Purified recombinant fragment of human AKT1 (AA: 1-150) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

WB 1/500 - 1/2000
IF 1/200 - 1/1000
FCM 1/200 - 1/400
ELISA 1/10000
联系我们
  • 电话:17771420241 18911818852
  • 联系人:刘经理
  • 地址:湖北省武汉市东湖新技术开发区高新大道666号光谷生物城C6栋C6403、C6404
微信公众号
版权所有 © 武汉博开生物科技有限公司  备案编号:鄂ICP备2024052832号-1鄂公网安备42018502007531号
17771420241 18911818852