Rabbit Monoclonal Antibody to IRF8
货号：
P21579
别名：
ICSBP; IRF-8; ICSBP1; IMD32A; IMD32B; H-ICSBP
应用：
WB,IP,IHC
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
Q02556
规格：
目录价
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Description |
|---|
Plays a role as a transcriptional activator or repressor (PubMed:25122610). Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes . |
Specification |
|
|---|---|
| Aliases | ICSBP; IRF-8; ICSBP1; IMD32A; IMD32B; H-ICSBP |
| Entrez GeneID | 3394 |
| Swissprot | Q02556 |
| WB Predicted band size | Calculated MW: 48 kDa; Observed MW: 48 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Recombinant protein of human IRF8 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
Application |
|
|---|---|
| WB | 1/500-1/1000 |
| IP | 1/10-1/20 |
| IHC | 1/50-1/100 |
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