Rabbit Monoclonal Antibody to kappa Opioid Receptor
货号:
P21594
别名:
KOR; R21; KOR-1; MSL-1; Oprk2; K-OR-1
应用:
WB,IP
反应种属:
Rat
抗体类型:
Primary antibody
Swissprot:
P33534
规格:
目录价
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Description |
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G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions. |
Specification |
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Aliases | KOR; R21; KOR-1; MSL-1; Oprk2; K-OR-1 |
Entrez GeneID | 18387 |
Swissprot | P33534 |
WB Predicted band size | Calculated MW: 43 kDa; Observed MW: 60 kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Rat |
Immunogen | A synthetic peptide of mouse Kappa Opioid Receptor |
Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
Application |
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WB | 1/500-1/1000 |
IP | 1/10-1/20 |