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Rabbit Monoclonal Antibody to kappa Opioid Receptor
货号: P21594
别名: KOR; R21; KOR-1; MSL-1; Oprk2; K-OR-1
应用: WB,IP
反应种属: Rat
抗体类型: Primary antibody
Swissprot: P33534
规格:
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Description

G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.

Specification

Aliases KOR; R21; KOR-1; MSL-1; Oprk2; K-OR-1
Entrez GeneID 18387
Swissprot P33534
WB Predicted band size Calculated MW: 43 kDa; Observed MW: 60 kDa
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Rat
Immunogen A synthetic peptide of mouse Kappa Opioid Receptor
Formulation Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

Application

WB 1/500-1/1000
IP 1/10-1/20
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