Rabbit Monoclonal Antibody to Lamin A/C
货号：
P21609
别名：
LMNA; LMN1; Prelamin-A/C
应用：
WB,IP,IHC,IF
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
P02545
规格：
目录价
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Description |
|---|
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Play an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence. |
Specification |
|
|---|---|
| Aliases | LMNA; LMN1; Prelamin-A/C |
| Entrez GeneID | 4000 |
| Swissprot | P02545 |
| WB Predicted band size | Calculated MW: 74 kDa; Observed MW: 74,63 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human Lamin A/C |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
Application |
|
|---|---|
| WB | 1/500-1/1000 |
| IP | 1/10-1/20 |
| IHC | 1/50-1/100 |
| IF | 1/50-1/200 |
Product Image
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Western blot analysis of Lamin A/C in rat heart, rat skeletal muscle lysates using Lamin A/C antibody.
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Western blot analysis of Lamin A/C in 3T3, Hela lysates using Lamin A/C antibody.
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Immunocytochemistry analysis of Lamin A/C(green) in Hela using Lamin A/C antibody,and DAPI(blue)
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Immunohistochemistry analysis of paraffin-embedded Human breast cancer using Lamin A/C antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
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