Rabbit Monoclonal Antibody to NELFE
货号:
P21738
别名:
RD; RDP; RDBP; D6S45; NELF-E
应用:
WB,IP,IHC
反应种属:
Human,Mouse,Rat
抗体类型:
Primary antibody
Swissprot:
P18615
规格:
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Description |
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Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1. |
Specification |
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Aliases | RD; RDP; RDBP; D6S45; NELF-E |
Entrez GeneID | 7936 |
Swissprot | P18615 |
WB Predicted band size | Calculated MW: 43 kDa; Observed MW: 43 kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human,Mouse,Rat |
Immunogen | Recombinant protein of human NELFe |
Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
Application |
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WB | 1/500-1/1000 |
IP | 1/10-1/20 |
IHC | 1/50-1/100 |