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Rabbit Monoclonal Antibody to NELFE
货号: P21738
别名: RD; RDP; RDBP; D6S45; NELF-E
应用: WB,IP,IHC
反应种属: Human,Mouse,Rat
抗体类型: Primary antibody
Swissprot: P18615
规格:
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Description

Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1.

Specification

Aliases RD; RDP; RDBP; D6S45; NELF-E
Entrez GeneID 7936
Swissprot P18615
WB Predicted band size Calculated MW: 43 kDa; Observed MW: 43 kDa
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human,Mouse,Rat
Immunogen Recombinant protein of human NELFe
Formulation Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

Application

WB 1/500-1/1000
IP 1/10-1/20
IHC 1/50-1/100
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