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Mouse Monoclonal Antibody to DNMT3L
货号: 30989
别名:
应用: FCM
反应种属: Human
抗体类型: Primary antibody
Swissprot: Q9UJW3
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Description

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

References

1.Clin Cancer Res. 2010 May 15;16(10):2751-9.
2.Epigenetics. 2009 Jul 1;4(5):322-9.

Specification

Entrez GeneID 29947
Swissprot Q9UJW3
clone 2D10H11
WB Predicted band size 43.6kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human DNMT3L (AA: 147-386) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

FCM 1/200 - 1/400
ELISA 1/10000
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