Mouse Monoclonal Antibody to DNMT3L
货号:
30989
别名:
应用:
FCM
反应种属:
Human
抗体类型:
Primary antibody
Swissprot:
Q9UJW3
规格:
目录价
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Description |
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CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
References |
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1.Clin Cancer Res. 2010 May 15;16(10):2751-9. 2.Epigenetics. 2009 Jul 1;4(5):322-9. |
Specification |
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Entrez GeneID | 29947 |
Swissprot | Q9UJW3 |
clone | 2D10H11 |
WB Predicted band size | 43.6kDa |
Host/Isotype | Mouse IgG1 |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | Purified recombinant fragment of human DNMT3L (AA: 147-386) expressed in E. Coli. |
Formulation | Purified antibody in PBS with 0.05% sodium azide |
Application |
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FCM | 1/200 - 1/400 |
ELISA | 1/10000 |
Product Image
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Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
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Flow cytometric analysis of Hela cells using DNMT3L mouse mAb (green) and negative control (red).
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Flow cytometric analysis of HepG2 cells using DNMT3L mouse mAb (green) and negative control (red).