Rabbit Monoclonal Antibody to Pellino 1
货号：
P21827
别名：
Pellino-related intracellular-signaling molecule; RING-type E3 ubiquitin transferase pellino homolog 1
应用：
WB,IP
反应种属：
Human,Rat
抗体类型：
Primary antibody
Swissprot：
Q96FA3
规格：
目录价
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Description |
|---|
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (PubMed:12496252, PubMed:17675297). Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3 (PubMed:29883609). Negatively regulates necroptosis by reducing RIPK3 [removed]PubMed:29883609). Mediates 'Lys-63'-linked ubiquitination of RIPK1 (PubMed:29883609). |
Specification |
|
|---|---|
| Aliases | Pellino-related intracellular-signaling molecule; RING-type E3 ubiquitin transferase pellino homolog 1 |
| Entrez GeneID | 57162 |
| Swissprot | Q96FA3 |
| WB Predicted band size | Calculated MW: 46 kDa; Observed MW: 46 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | Recombinant protein of human Pellino 1 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
Application |
|
|---|---|
| WB | 1/500-1/1000 |
| IP | 1/10-1/20 |
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