Mouse Monoclonal Antibody to CHK1
货号：
20031
别名：
CHEK1
应用：
WB
反应种属：
Human,Mouse
抗体类型：
Primary antibody
Swissprot：
O14757
规格：
目录价
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Description |
|---|
CHK1, also known as CHEK1, it is a kinase that phosphorylates cdc25, an important phosphatase in cell cycle control, particularly for entry into mitosis. Cdc25, when phosphorylated on serine 216 by chk1 becomes bound by an adaptor protein in the cytoplasm. Therefore it is inhibited from removing the inhibiting phosphate from MPF (mitotic/maturation promoting factor) added by Wee1. Consequently, a cell is prevented from entering mitosis. Chk1 can also phosphorylate p53 at Ser20 in vitro. |
References |
|---|
| 1. EMBO J. 1998. 16: 545-554. 2. Science 1998. 282: 1893-1897. |
Specification |
|
|---|---|
| Aliases | CHEK1 |
| Entrez GeneID | 1111 |
| Swissprot | O14757 |
| clone | 2G1D5 |
| WB Predicted band size | 56kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Purified recombinant fragment of CHK1 expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500 - 1/2000 |
| ELISA | 1/10000 |
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