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Mouse Monoclonal Antibody to CD274
货号: 31027
别名: B7-H; B7H1; PDL1; PD-L1; PDCD1L1; PDCD1LG1
应用: FCM
反应种属: Human
抗体类型: Primary antibody
Swissprot: Q9NZQ7
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Description

This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.

References

1.Anticancer Res. 2015 Oct;35(10):5369-76.
2.Lung Cancer. 2015 Jun;88(3):254-9.

Specification

Aliases B7-H; B7H1; PDL1; PD-L1; PDCD1L1; PDCD1LG1
Entrez GeneID 29126
Swissprot Q9NZQ7
clone 7D2A10
WB Predicted band size 33.3kDa
Host/Isotype Mouse IgG2b
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human CD274 (AA: 24-153) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

FCM 1/200 - 1/400
ELISA 1/10000
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