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Mouse Monoclonal Antibody to ALK
货号: 31080
别名: CD246; NBLST3
应用: IF,FCM
反应种属: Human
抗体类型: Primary antibody
Swissprot: Q9UM73
规格:
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Description

This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).

References

1.Nature. 2015 Oct 15;526(7573):453-7.
2.Breast Cancer Res. 2015 Sep 17;17:127.

Specification

Aliases CD246; NBLST3
Entrez GeneID 238
Swissprot Q9UM73
clone 7A11A4
WB Predicted band size 176kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human ALK (AA: 1366-1468) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

IF 1/50 - 1/250
FCM 1/200 - 1/400
ELISA 1/10000
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