Mouse Monoclonal Antibody to cTnI
货号：
20050
别名：
CMH7; RCM1; cTnI; CMD2A; TNNC1
应用：
IHC
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
P19429
规格：
目录价
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Description |
|---|
cTnI has an apparent molecular weight of 22.5 kDa. cTnI is a candidate marker with acceptable sensitivity and specificity for AMI and other cardiac diseases. Troponin, a molecule that binds to the thin filament (actin) of striated muscle fibers, acts with intracellular calcium to control the interaction of the thin filament with the thick filament (myosin), thus regulating muscle contraction. Troponin I prevents muscle contraction in the absence of calcium, which has two skeletal muscle isoforms with considerable amino acid sequence homology. cTnI contains an additional N-terminal sequence and is highly specific for myocardium. |
References |
|---|
| 1. Cummins B and Cummins P, J Mol Cell Cardiol, 1987, 19(10):999-1010. 2. Cummins B, Auckland ML, and Cummins P, Am Heart J, 1987, 113(6):1333-44. 3. Darnell J, Lodish H, and Baltimore D, Molecular Cell Biology, New York, NY: Scientific American Books, 1986, 827-8. 4. Larue C, Defacque-Lacquemant H, Calzolari C, et al, Mol Immunol, 1992, 29(2):271-8. 5. Adams JE III, Bodor GS, Davila-Roman VG, et al, Circulation, 1993, 88(1):101-6. |
Specification |
|
|---|---|
| Aliases | CMH7; RCM1; cTnI; CMD2A; TNNC1 |
| Entrez GeneID | 7137 |
| Swissprot | P19429 |
| clone | 3A10A12 |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of cTnI expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
Application |
|
|---|---|
| IHC | 1/200 - 1/1000 |
| ELISA | 1/10000 |
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