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Mouse Monoclonal Antibody to MCL-1
货号: 20027
别名: EAT, MCL1L, MCL1S
应用: WB,IHC,IF
反应种属: Human
抗体类型: Primary antibody
Swissprot: Q07820
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Description

Mcl-1 (Myeloid cell leukemia-1) is Bcl-2-related and was identified as an early-induction gene that
increased in expression during the differentiation of human myeloblastic leukemia cell ML-1, or
exposure to different DNA damaging agents. The level of Mcl-1 is decreased in peripheral B lymphocytes undergoing apoptosis following treatment with apoptotic stimuli such as TGF-alpha 1 and forskolin. Expression of Mcl-1 is able to delay apoptosis induced by over-expression of c-myc in CHO 5AHSmyc cells. In hematopoietic FDC-P1 cells, Mcl-1 interacts with another Bcl-2-related
protein, Bax, and prolongs cell viability after treatment with different apoptotic reagents.This
monoclonal antibody detected a 37kd MCL1 in BCBL-1 cell lysate.

References

1. Ota, N. et al. J. Hum. Genet. 2000. 46: 254-269.
2. Schwertfeger KL, Ryder JW, Anderson SM J Mammary Gland Biol Neoplasia 2000, 3 : 236-251.

Specification

Aliases EAT, MCL1L, MCL1S
Entrez GeneID 4170
Swissprot Q07820
clone 8C6D4B1
WB Predicted band size 37kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human MCL-1 expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

WB 1/500 - 1/2000
IHC 1/200 - 1/1000
IF 1/200 - 1/1000
ELISA 1/10000
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