Mouse Monoclonal Antibody to ALK
货号:
31112
别名:
CD246; NBLST3
应用:
FCM
反应种属:
Human
抗体类型:
Primary antibody
Swissprot:
Q9UM73
规格:
目录价
在线咨询
Description |
---|
This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X). |
References |
---|
1.Breast Cancer Res. 2015 Sep 17;17:127. 2.J Cancer Res Clin Oncol. 2014 Sep;140(9):1625-8. |
Specification |
|
---|---|
Aliases | CD246; NBLST3 |
Entrez GeneID | 238 |
Swissprot | Q9UM73 |
clone | 8E8D3 |
WB Predicted band size | 176kDa |
Host/Isotype | Mouse IgG1 |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | Purified recombinant fragment of human ALK (AA: 1366-1468) expressed in E. Coli. |
Formulation | Purified antibody in PBS with 0.05% sodium azide |
Application |
|
---|---|
FCM | 1/200 - 1/400 |
ELISA | 1/10000 |
Product Image
-
Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
-
Flow cytometric analysis of HepG2 cells using ALK mouse mAb (green) and negative control (red).
-
Immunohistochemical analysis of paraffin-embedded human Hela tissues using ALK mouse mAb with DAB staining.