Mouse Monoclonal Antibody to ER-alpha
货号:
20047
别名:
ER; ESR1; Era; ESRA
应用:
WB,IHC
反应种属:
Human
抗体类型:
Primary antibody
Swissprot:
P03372
规格:
目录价
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Description |
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The estrogen receptor (ER) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Alternative splicing results in several ER mRNA transcripts, which differ primarily in their 5-prime untranslated regions. Two isoforms of the human ER, ERA and ER-beta, occur, each with distinct tissue and cell patterns of expression. Pelletier and El-Alfy (2000) studied the immunocytochemical localization of ESRA and ESRB in human reproductive tissues. In the ovary, ERB immunoreactivity was found in nuclei of granulosa cells of growing follicles at all stages from primary to mature follicles, interstitial gland, and germinal epithelium cells. Nuclear staining for ERA occurred in thecal, interstitial gland, and germinal epithelium cells. In the uterus, strong ERA immunoreactivity was detected in nuclei of epithelial, stromal, and muscle cells. |
References |
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1. Paech K. Science 1997, 277: 1508- 10. 2. Pertschuk LP,Cancer, 1996. 199677: 514- 9. |
Specification |
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Aliases | ER; ESR1; Era; ESRA |
Entrez GeneID | 2099 |
Swissprot | P03372 |
clone | 2B7 |
Host/Isotype | Mouse IgG1 |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | Purified recombinant fragment of human ER-alpha (410-592aa) expressed in E. Coli. |
Formulation | Purified antibody in PBS with 0.05% sodium azide |
Application |
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WB | 1/500 - 1/2000 |
IHC | 1/200 - 1/1000 |
ELISA | 1/10000 |