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Mouse Monoclonal Antibody to CCND1
货号: 31137
别名: BCL1; PRAD1; U21B31; D11S287E
应用: IHC,IF,FCM
反应种属: Human
抗体类型: Primary antibody
Swissprot: P24385
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Description

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.

References

1.BMC Cancer. 2015 Apr 11;15:262.
2.Tumour Biol. 2015 Aug;36(8):6533-40.

Specification

Aliases BCL1; PRAD1; U21B31; D11S287E
Entrez GeneID 595
Swissprot P24385
clone 3B6G3
WB Predicted band size 33.7kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human CCND1 (AA: 167-295) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

IHC 1/200 - 1/1000
IF 1/100 - 1/500
FCM 1/200 - 1/400
ELISA 1/10000
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