Rabbit Polyclonal Antibody to 4E BP1
货号：
P23596
别名：
EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I
应用：
WB,IP
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
Q13541
规格：
目录价
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Description |
|---|
Translation repressor protein 4E-BP1 (also known as PHAS-1) inhibits cap-dependent translation by binding to the translation initiation factor eIF4E. Hyperphosphorylation of 4E-BP1 disrupts this interaction and results in activation of cap-dependent translation. Both the PI3 kinase/Akt pathway and FRAP/mTOR kinase regulate 4E-BP1 activity. |
Specification |
|
|---|---|
| Aliases | EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I |
| Entrez GeneID | 1978 |
| Swissprot | Q13541 |
| WB Predicted band size | Calculated MW: 13 kDa; Observed MW: 15-20 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic peptide. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
Application |
|
|---|---|
| WB | 1/500-1/1000 |
| IP | 1/10-1/20 |
Product Image
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Western blot analysis of 4EBP1 in SH-SY5Y, C2C12 and 3T3 lysates using 4EBP1 antibody.
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Western blot analysis of 4E BP1 in Jurkat, Hela and C6 lysates using 4EBP1 antibody.
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Western blot analysis of 4E BP1 in C2C12, A549 and 3T3 lysates using 4E BP1 antibody
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Immunoprecipitation analysis of 4E BP1 in Hela lysates using 4EBP1 antibody.
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