Rabbit Polyclonal Antibody to JMJD4 (N-term)
货号：
P30177
别名：
JmjC domain-containing protein 4, Jumonji domain-containing protein 4, JMJD4
应用：
WB
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
Q9H9V9
规格：
目录价
在线咨询
Description |
|---|
Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed. |
Specification |
|
|---|---|
| Aliases | JmjC domain-containing protein 4, Jumonji domain-containing protein 4, JMJD4 |
| Entrez GeneID | 65094 |
| Swissprot | Q9H9V9 |
| WB Predicted band size | 52.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This JMJD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human JMJD4. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/1000 |
鄂公网安备42018502007531号
