Rabbit Polyclonal Antibody to Phospho-TSC2(S1420)
货号：
P30309
别名：
Tuberin, Tuberous sclerosis 2 protein, TSC2, TSC4
应用：
WB,IF
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
P49815
规格：
目录价
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Description |
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Mutations in TSC2 lead to tuberous sclerosis complex. The protein is believed to be a tumor suppressor and is able to specifically stimulate the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. TSC2 may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking. |
Specification |
|
|---|---|
| Aliases | Tuberin, Tuberous sclerosis 2 protein, TSC2, TSC4 |
| Entrez GeneID | 7249 |
| Swissprot | P49815 |
| WB Predicted band size | 200.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TSC2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1420 of human TSC2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | DB: 1/500 |
| IF | 1/10-1/50 |
Product Image
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Dot blot analysis of anti-TSC2-pS1420 Phospho-specific Pab on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.
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Confocal immunofluorescent analysis of Phospho-TSC2-S1420 Antibody(Cat#P30309) with MCF-7 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red).DAPI was used to stain the cell nuclear (blue).
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