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Mouse Monoclonal Antibody to APEX1
货号: 31203
别名: APE; APX; APE1; APEN; APEX; HAP1; REF1
应用: WB,IHC,FCM
反应种属: Human,Rat,Monkey
抗体类型: Primary antibody
Swissprot: P27695
规格:
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Description

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.

References

1.Mutat Res Genet Toxicol Environ Mutagen. 2015 Nov;793:19-29.
2.PLoS One. 2015 Dec 1;10(12):e0143289.

Specification

Aliases APE; APX; APE1; APEN; APEX; HAP1; REF1
Entrez GeneID 328
Swissprot P27695
clone 7A2G7
WB Predicted band size 35.6kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human,Rat,Monkey
Immunogen Purified recombinant fragment of human APEX1 (AA: 219-318) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

WB 1/500 - 1/2000
IHC 1/200 - 1/1000
FCM 1/200 - 1/400
ELISA 1/10000
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