Rabbit Polyclonal Antibody to FZD6
货号:
P30892
别名:
Frizzled-6, Fz-6, hFz6, FZD6
应用:
WB
反应种属:
Human
抗体类型:
Primary antibody
Swissprot:
O60353
规格:
目录价
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Description |
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This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants. |
Specification |
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Aliases | Frizzled-6, Fz-6, hFz6, FZD6 |
Entrez GeneID | 8323 |
Swissprot | O60353 |
WB Predicted band size | 79.3kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | This FZD6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 493-520 amino acids from the Central region of human FZD6. |
Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
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WB | 1/1000 |