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Mouse Monoclonal Antibody to CHRNA2
货号: 31267
别名:
应用: WB
反应种属: Human,Rat
抗体类型: Primary antibody
Swissprot: Q15822
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Description

Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence.

References

1.Hum Genet. 2014 May;133(5):575-86.
2.Epilepsia. 2015 May;56(5):e53-7.

Specification

Entrez GeneID 1135
Swissprot Q15822
clone 7G12H9
WB Predicted band size 60kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human,Rat
Immunogen Purified recombinant fragment of human CHRNA2 (AA: extra 27-264) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

WB 1/500 - 1/2000
ELISA 1/10000
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