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Mouse Monoclonal Antibody to B7H3
货号: 31371
别名: CD276; B7-H3; B7RP-2; 4Ig-B7-H3
应用: IHC,IF,FCM
反应种属: Human
抗体类型: Primary antibody
Swissprot: Q5ZPR3
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Description

The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

References

1.Int J Clin Exp Pathol. 2015 Nov 1;8(11):13987-95.
2.BMC Cancer. 2014 Aug 20;14:602.

Specification

Aliases CD276; B7-H3; B7RP-2; 4Ig-B7-H3
Entrez GeneID 80381
Swissprot Q5ZPR3
clone 8C1C2
WB Predicted band size 57.2kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human B7H3 (AA: extra 29-466) expressed in HEK293 cells.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

IHC 1/200 - 1/1000
IF 1/100 - 1/500
FCM 1/200 - 1/400
ELISA 1/10000
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