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Rabbit Polyclonal Antibody to CHRNG (N-term)
货号: P31742
别名: Acetylcholine receptor subunit gamma, CHRNG, ACHRG
应用: WB
反应种属: Human
抗体类型: Primary antibody
Swissprot: P07510
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Description

The mammalian muscle-type acetylcholine receptor is a transmembrane pentameric glycoprotein with two alpha subunits, one beta, one delta, and one epsilon (in adult skeletal muscle) or gamma (in fetal and denervated muscle) subunit. This gene, which encodes the gamma subunit, is expressed prior to the thirty-third week of gestation in humans. The gamma subunit of the acetylcholine receptor plays a role in neuromuscular organogenesis and ligand binding and disruption of gamma subunit expression prevents the correct localization of the receptor in cell membranes. Mutations in this gene cause Escobar syndrome and a lethal form of multiple pterygium syndrome. Muscle-type acetylcholine receptor is the major antigen in the autoimmune disease myasthenia gravis.

Specification

Aliases Acetylcholine receptor subunit gamma, CHRNG, ACHRG
Entrez GeneID 1146
Swissprot P07510
WB Predicted band size 57.9kDa
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen This CHRNG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22-50 amino acids from the N-terminal region of human CHRNG.
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

WB 1/1000
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