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Mouse Monoclonal Antibody to CD197
货号: 31345
别名: BLR2; EBI1; CCR-7; CCR7; CDw197; CMKBR7; CC-CKR-7
应用: WB,FCM
反应种属: Human
抗体类型: Primary antibody
Swissprot: P32248
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Description

The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants.

References

1.Gastric Cancer. 2017 Mar;20(2):235-245.
2.J Surg Oncol. 2015 Jul;112(1):86-92.

Specification

Aliases BLR2; EBI1; CCR-7; CCR7; CDw197; CMKBR7; CC-CKR-7
Entrez GeneID 1236
Swissprot P32248
clone 4B7B8
WB Predicted band size 42.9kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human CD197 (AA: extra mix) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

WB 1/500 - 1/2000
FCM 1/200 - 1/400
ELISA 1/10000
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