Rabbit Polyclonal Antibody to THOC6
货号：
P32015
别名：
THO complex subunit 6 homolog, Functional spliceosome-associated protein 35, fSAP35, WD repeat-containing protein 58, THOC6, WDR58
应用：
WB
反应种属：
Human, Mouse
抗体类型：
Primary antibody
Swissprot：
Q86W42
规格：
目录价
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Description |
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Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing-and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between THOC4 and the cap-binding protein NCBP1. UAP56 functions as a bridge between THOC4 and the THO complex. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and THOC4. |
Specification |
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|---|---|
| Aliases | THO complex subunit 6 homolog, Functional spliceosome-associated protein 35, fSAP35, WD repeat-containing protein 58, THOC6, WDR58 |
| Entrez GeneID | 79228 |
| Swissprot | Q86W42 |
| WB Predicted band size | 37.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This THOC6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96-123 amino acids from the Central region of human THOC6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
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|---|---|
| WB | 1/1000 |
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