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Mouse Monoclonal Antibody to CD1C
货号: 31404
别名: R7; CD1; CD1A; BDCA1
应用: IHC,FCM
反应种属: Human
抗体类型: Primary antibody
Swissprot: P29017
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Description

This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail. Alternatively spliced transcript variants of this gene have been observed, but their full-length nature is not known.

References

1.Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1266-75.
2.J Exp Med. 2014 Jun 30;211(7):1363-77.

Specification

Aliases R7; CD1; CD1A; BDCA1
Entrez GeneID 911
Swissprot P29017
clone 2A7C11
WB Predicted band size 37.7kDa
Host/Isotype Mouse IgG2b
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human CD1C (AA: extra 18-302) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

IHC 1/200 - 1/1000
FCM 1/200 - 1/400
ELISA 1/10000
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