Rabbit Polyclonal Antibody to SGOL2
货号：
P32356
别名：
Shugoshin-like 2, Shugoshin-2, Sgo2, Tripin, SGOL2
应用：
WB
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
Q562F6
规格：
目录价
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Description |
|---|
Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. |
Specification |
|
|---|---|
| Aliases | Shugoshin-like 2, Shugoshin-2, Sgo2, Tripin, SGOL2 |
| Entrez GeneID | 151246 |
| Swissprot | Q562F6 |
| WB Predicted band size | 144.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SGOL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-419 amino acids from the Central region of human SGOL2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/1000 |
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