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Mouse Monoclonal Antibody to CD40
货号: 31425
别名: p50; Bp50; CDW40; TNFRSF5
应用: FCM
反应种属: Human
抗体类型: Primary antibody
Swissprot: P25942
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Description

This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

References

1.Anticancer Res. 2016 Sep;36(9):4467-75.
2.Med Oncol. 2015 Mar;32(3):63.

Specification

Aliases p50; Bp50; CDW40; TNFRSF5
Entrez GeneID 958
Swissprot P25942
clone 4C3B8
WB Predicted band size 30.6kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human CD40 (AA: extra 21-193) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

FCM 1/200 - 1/400
ELISA 1/10000
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