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Mouse Monoclonal Antibody to CD45
货号: 31446
别名: PTPRC; LCA; LY5; B220; L-CA; T200; CD45R; GP180
应用: IHC,FCM
反应种属: Human
抗体类型: Primary antibody
Swissprot: P08575
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Description

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.

References

1.J Allergy Clin Immunol. 2016 Sep;138(3):839-851.e8. 2.Haematologica. 2014 Jan;99(1):103-10.

Specification

Aliases PTPRC; LCA; LY5; B220; L-CA; T200; CD45R; GP180
Entrez GeneID 5788
Swissprot P08575
clone 1B9B10
WB Predicted band size 147.3kDa
Host/Isotype Mouse IgG2b
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human CD45 (AA: extra 431-577) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

IHC 1/200 - 1/1000
FCM 1/200 - 1/400
ELISA 1/10000
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