Rabbit Polyclonal Antibody to ERN2 (N-term)
货号：
P32746
别名：
Serine/threonine-protein kinase/endoribonuclease IRE2, Endoplasmic reticulum-to-nucleus signaling 2, Inositol-requiring protein 2, hIRE2p, Ire1-beta, IRE1b, Serine/threonine-protein kinase, Endoribonuclease
应用：
WB
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
Q76MJ5
规格：
目录价
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Description |
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ERN2 induces translational repression through 28S ribosomal RNA cleavage in response to endoplasmic reticulum (ER) stress. This pro-apoptotic appears to play no role in the unfolded-protein response, unlike closely related proteins. Overexpression of ERN2 activates both BiP and CHOP expression, and also leads to the development of programmed cell death. It has been suggested that Ern2 plays a role in multiple facets of the ER stress response in mammalian cells. |
Specification |
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|---|---|
| Aliases | Serine/threonine-protein kinase/endoribonuclease IRE2, Endoplasmic reticulum-to-nucleus signaling 2, Inositol-requiring protein 2, hIRE2p, Ire1-beta, IRE1b, Serine/threonine-protein kinase, Endoribonuclease |
| Entrez GeneID | 10595 |
| Swissprot | Q76MJ5 |
| WB Predicted band size | 102.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ERN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-72 amino acids from the N-terminal region of human ERN2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
Application |
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| WB | 1/1000 |
Product Image
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Western blot analysis of lysate from HT-29 cell line, using ERN2 Antibody (N-term)(Cat. #P32746). P32746 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 35ug.
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Western blot analysis of ERN2 N-term (Cat. #P32746) in mouse stomach tissue lysates (35ug/lane). ERN2 (arrow) was detected using the purified Pab.
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