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Rabbit Polyclonal Antibody to (Mouse) Epha1
货号: P33000
别名: Ephrin type-A receptor 1, mEpha1, Embryonic stem cell kinase, Tyrosine-protein kinase receptor ESK, Epha1, Esk
应用: WB
反应种属: Human, Mouse
抗体类型: Primary antibody
Swissprot: Q60750
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Description

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.

Specification

Aliases Ephrin type-A receptor 1, mEpha1, Embryonic stem cell kinase, Tyrosine-protein kinase receptor ESK, Epha1, Esk
Entrez GeneID 13835
Swissprot Q60750
WB Predicted band size 108.6kDa
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human, Mouse
Immunogen This mouse Epha1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 453-487 amino acids from the Central region of mouse Epha1.

Application

WB 1/2000
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