Rabbit Polyclonal Antibody to WWP2 (N-term)
货号：
P33016
别名：
NEDD4-like E3 ubiquitin-protein ligase WWP2, 632-, Atrophin-1-interacting protein 2, AIP2, WW domain-containing protein 2, WWP2
应用：
WB
反应种属：
Human, Mouse
抗体类型：
Primary antibody
Swissprot：
O00308
规格：
目录价
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Description |
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E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation- induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation. |
Specification |
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|---|---|
| Aliases | NEDD4-like E3 ubiquitin-protein ligase WWP2, 632-, Atrophin-1-interacting protein 2, AIP2, WW domain-containing protein 2, WWP2 |
| Entrez GeneID | 11060 |
| Swissprot | O00308 |
| WB Predicted band size | 98.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This WWP2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 218-252 amino acids from the N-terminal region of human WWP2. |
Application |
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| WB | 1/1000 |
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