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Mouse Monoclonal Antibody to CD87
货号: 31502
别名: PLAUR; UPAR; URKR; U-PAR
应用: FCM
反应种属: Human
抗体类型: Primary antibody
Swissprot: Q03405 
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Description

This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined.

References

1.Biomark Med. 2016;10(2):209-16.
2.Andrology. 2015 Nov;3(6):1054-61.

Specification

Aliases PLAUR; UPAR; URKR; U-PAR
Entrez GeneID 5329
Swissprot Q03405 
clone 1D1B11
WB Predicted band size 37kDa
Host/Isotype Mouse IgG2b
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human CD87 (AA: 23-305) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

FCM 1/200 - 1/400
ELISA 1/10000
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