Rabbit Polyclonal Antibody to RSPO1
货号：
P33634
别名：
R-spondin-1, Roof plate-specific spondin-1, hRspo1, RSPO1
应用：
WB
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
Q2MKA7
规格：
目录价
在线咨询
Description |
|---|
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. |
Specification |
|
|---|---|
| Aliases | R-spondin-1, Roof plate-specific spondin-1, hRspo1, RSPO1 |
| Entrez GeneID | 284654 |
| Swissprot | Q2MKA7 |
| WB Predicted band size | 29.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This RSPO1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 206-240 amino acids from human RSPO1. |
Application |
|
|---|---|
| WB | 1/2000 |
鄂公网安备42018502007531号
