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Mouse Monoclonal Antibody to CD53
货号: 31520
别名: MOX44; TSPAN25
应用: WB,IHC,FCM
反应种属: Human
抗体类型: Primary antibody
Swissprot: P19397
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Description

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. Alternative splicing results in multiple transcript variants.

References

1.Biochim Biophys Acta. 2013 Apr;1830(4):3011-8.
2.Eur J Hum Genet. 2010 Aug;18(8):953-9.

Specification

Aliases MOX44; TSPAN25
Entrez GeneID 963
Swissprot P19397
clone 7A8D3
WB Predicted band size 24.3kDa
Host/Isotype Mouse IgG2a
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human CD53 (AA: extra mix) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

WB 1/500 - 1/2000
IHC 1/200 - 1/1000
FCM 1/200 - 1/400
ELISA 1/10000
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