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Mouse Monoclonal Antibody to MAP2K4
货号: 20097
别名: MAP2K4
应用: IHC
反应种属: Human
抗体类型: Primary antibody
Swissprot: P45985
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Description

MAP2K4(mitogen-activated protein kinase kinase 4), which is located on chromosome 17p11.2, with 399-amino acid protein (about 45 kDa), belongs to the family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. MEK-4 (also called MEK4/MKK4) activates both p38 and JNK MAP kinases.
MKK4 is a central mediator in the stress activated protein kinase signaling pathway that responds to a number of cellular and environmental stressors. By phosphorylating MAP kinases such as JNK,MKK4 can ultimately transmit stress signals to nuclear transcription factors that mediate various processes including proliferation, apoptosis, and differentiation. Its distinct biological functions have been identified for MKK4 including a role in development, hepatogenesis, and metastasis suppression.

References

1. Crews, C.M, et al. 1992. Science. 258: 478-480.
2. Cuenda A. 2000. Int. J. Biochem. Cell Biol, 32: 581-587.
3. Kim H. L, Vander Griend D. J, Yang X, et al. 2001.Cancer Res. 61: 2833-2837.

Specification

Aliases MAP2K4
Entrez GeneID 6416
Swissprot P45985
clone 2D10D8
Host/Isotype Mouse IgM
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of MAP2K4 expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.

Application

IHC 1/200 - 1/1000
ELISA 1/10000
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