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Mouse Monoclonal Antibody to CD125
货号: 31604
别名: IL5RA; IL5R; CDw125; HSIL5R3
应用: FCM
反应种属: Human
抗体类型: Primary antibody
Swissprot: Q01344 
规格:
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Description

The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported.

References

1.Exp Mol Med. 2013 Mar 8;45:e14.
2.J Allergy Clin Immunol. 2011 Nov;128(5):1086-92.e1-3.

Specification

Aliases IL5RA; IL5R; CDw125; HSIL5R3
Entrez GeneID 3568
Swissprot Q01344 
clone 5E12F5D6
WB Predicted band size 47.7kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human CD125 (AA: extra 21-196) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

FCM 1/200 - 1/400
ELISA 1/10000
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