Rabbit Polyclonal Antibody to Mouse Dnmt3b
货号：
P35117
别名：
DNA (cytosine-5)-methyltransferase 3B, Dnmt3b, DNA methyltransferase MmuIIIB, DNA MTase MmuIIIB, MMmuIIIB, Dnmt3b
应用：
WB
反应种属：
Mouse
抗体类型：
Primary antibody
Swissprot：
O88509
规格：
目录价
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Description |
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Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co- repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Function as transcriptional corepressor by associating with ZHX1 (By similarity). |
Specification |
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|---|---|
| Aliases | DNA (cytosine-5)-methyltransferase 3B, Dnmt3b, DNA methyltransferase MmuIIIB, DNA MTase MmuIIIB, MMmuIIIB, Dnmt3b |
| Entrez GeneID | 13436 |
| Swissprot | O88509 |
| WB Predicted band size | 97.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Mouse |
| Immunogen | This Mouse Dnmt3b antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 356-390 amino acids from the Central region of Mouse Dnmt3b. |
Application |
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| WB | 1/500 |
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