Rabbit Polyclonal Antibody to BAD(Phospho-Ser112)
货号：
P40066
别名：
Bbc2
应用：
WB,IHC
反应种属：
Human,Mouse
抗体类型：
Primary antibody
Swissprot：
Q61337
规格：
目录价
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Description |
|---|
The protein encoded by BAD gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. |
References |
|---|
| Zhang B, et al. (2004). Mol Cell Biol.24 (14): 6205-6214. Rice PL, et al. (2003). Cancer Res.63 (3): 616-620. Wang XQ, et al. (2001). J Biol Chem.276 (48): 44504-44511. |
Specification |
|
|---|---|
| Aliases | Bbc2 |
| Entrez GeneID | 12015; |
| Swissprot | Q61337 |
| WB Predicted band size | 23kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Peptide sequence around phosphorylation site of serine 112 (H-S-S(p)-Y-P) derived from Mouse BAD. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/1000 |
| IHC | 1/50-1/100 |
Product Image
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Western blot analysis of extracts from cos7 cells untreated or treated with EGF using BAD(Phospho-Ser112) Antibody P40066
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Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using BAD(Phospho-Ser112) Antibody P40066(left) or the same antibody preincubated with blocking peptide(right).
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